Mechanisms by which Exercise effects Cardiovascular Health in Models of Chronic Spinal Cord Injury
This project will use a model of long-term SCI to gain an understanding of the mechanisms of cardiovascular dysfunction and the effects of exercise. These models will allow us to examine the mechanisms underlying the effects of long-term SCI and exercise interventions on cardiovascular health. Previously, our team has used this technique to characterize vascular dysfunction in models of tobacco exposure and diabetes, and to study the effects of exercise in these models. This project is a unique opportunity to gain bench-to-bedside insight into cardiovascular dysfunction after SCI.
This project aims to establish baseline vascular function and secondary cardiovascular and metabolic measures in models of long-term SCI. We will also evaluate the effects of exercise on vascular function and secondary clinical and molecular outcomes in long-term SCI.